KLF12 overcomes anti-PD-1 resistance by reducing galectin-1 in cancer cells

Backgrounds Immune checkpoint blockade has revolutionized cancer treatment and has improved the survival of a subset of patients with cancer. However, numerous patients do not benefit from immunotherapy, and treatment resistance is a major challenge. Krüppel-like factor 12 (KLF12) is a transcription...

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Bibliographic Details
Main Authors: Hao Zhang, Jie He, Chunxiang Li, Tao Fan, Bo Zheng, Chu Xiao, Yujia Zheng, Ziqin Deng
Format: Article
Language:English
Published: BMJ Publishing Group 2023-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/8/e007286.full