ATF3 Suppresses Growth and Metastasis of Clear Cell Renal Cell Carcinoma by Deactivating EGFR/AKT/GSK3β/β-Catenin Signaling Pathway

ATF3 Suppresses Growth and Metastasis of Clear Cell Renal Cell Carcinoma by Deactivating EGFR/AKT/GSK3β/β-Catenin Signaling Pathway

BackgroundClear cell renal cell carcinoma (ccRCC) is one of the most common malignant cancers in East Asia, with high incidence and mortality. Accumulating evidence has shown that ATF3 is associated with tumor progression.MethodsUsing qPCR, the expression of ATF3 was detected in 93 patients with ccR...

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Bibliographic Details
Main Authors: Shenglin Gao, Lei Gao, Simin Wang, Xiaokai Shi, Chuang Yue, Shuzhang Wei, Li Zuo, Lifeng Zhang, Xihu Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
clear cell renal cell carcinoma
activation transcription factor 3
growth
metastasis
GSEA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.618987/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.618987/full

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