Antiproliferative Efficacy of <i>N</i>-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis

Antiproliferative Efficacy of <i>N</i>-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis

A novel series of 4-anilinoquinazoline analogues, <b>DW (1–10)</b>, were evaluated for anticancer efficacy in human breast cancer (BT-20) and human colorectal cancer (CRC) cell lines (HCT116, HT29, and SW620). The compound, <b>DW-8</b>, had the highest anticancer efficacy and...

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Bibliographic Details
Main Authors: Rabin Neupane, Saloni Malla, Mariam Sami Abou-Dahech, Swapnaa Balaji, Shikha Kumari, Digambar Kumar Waiker, N. S. Hari Narayana Moorthy, Piyush Trivedi, Charles R. Ashby, Chandrabose Karthikeyan, Amit K. Tiwari
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
colorectal cancer
cytotoxicity
4-anilino-quinazoline
intrinsic apoptosis
anticancer compound
Online Access:https://www.mdpi.com/1420-3049/26/15/4417

Internet

https://www.mdpi.com/1420-3049/26/15/4417

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