Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

Cytochrome P450 (CYP) 3A7 is one of the major xenobiotic metabolizing enzymes in human embryonic, fetal, and newborn liver. CYP3A7 expression has also been observed in a subset of the adult population, including pregnant women, as well as in various cancer patients. The characterization of CYP3A7 is...

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Bibliographic Details
Main Authors: Md Kabir, Elias C. Padilha, Pranav Shah, Ruili Huang, Srilatha Sakamuru, Eric Gonzalez, Lin Ye, Xin Hu, Mark J. Henderson, Menghang Xia, Xin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
cytochrome P450
CYP3A7
CYP3A4
drug metabolism
qHTS data analysis
neonates
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.899536/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.899536/full

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