Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway.

Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway.

BACKGROUND: sAPPα released after α secretase cleavage of Amyloid Precursor Protein (APP) has several functions including the stimulation of neurite outgrowth although detailed morphometric analysis has not been done. Two domains involved in this function have been described and are present in sAPPβ...

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Bibliographic Details
Main Authors: Stéphanie Chasseigneaux, Levent Dinc, Christiane Rose, Claude Chabret, Fanny Coulpier, Piotr Topilko, Gweltas Mauger, Bernadette Allinquant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3029320?pdf=render

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http://europepmc.org/articles/PMC3029320?pdf=render

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