Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of α4 integrin- and CXCR4-mediated engraftment in NOD/SCID β2-microglobulin-null mice
Background Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of α4 integrin, α5 integrin and CXCR4 in engraftment of unmanipulated and cytokine-treated human cord blood CD34+ cells.Design and Methods Unc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2009-02-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/5157 |