Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment

Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment

Low-density lipoprotein (LDL) receptor (LDLR) mutations are the primary cause of familial hypercholesterolemia (FH). Class II LDLR mutations result in a misfolded LDLR retained in the endoplasmic reticulum (ER). We have developed a model of FH class II and CRISPR-corrected induced pluripotent stem c...

Full description

Bibliographic Details
Main Authors: Linda Omer, Lubna Hindi, Giuseppe Militello, Katlin B. Stivers, Kenneth C. Tien, Nolan L. Boyd
Format: Article
Language:English
Published: The Company of Biologists 2020-04-01
Series:Disease Models & Mechanisms
Subjects:
familial hypercholesterolemia
low-density lipoprotein
cholesterol
endoplasmic reticulum stress
clustered regularly interspersed palindromic repeats
Online Access:http://dmm.biologists.org/content/13/4/dmm042911

Internet

http://dmm.biologists.org/content/13/4/dmm042911

Similar Items