BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

Objective: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. Here, we exam...

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Bibliographic Details
Main Authors: Jenny M. Hoffmann, John R. Grünberg, Ann Hammarstedt, Tobias Kroon, Thomas U. Greiner, Stefanie Maurer, Ivet Elias, Vilborg Palsdottir, Fatima Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877819309482

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http://www.sciencedirect.com/science/article/pii/S2212877819309482

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