TRAF-STOP alleviates osteoclastogenesis in periodontitis

TRAF-STOP alleviates osteoclastogenesis in periodontitis

The enhanced osteoclastogenesis contributes to alveolar bone resorption in periodontitis, which increases the risk of tooth loss. To reduce bone destruction, the inhibition of osteoclast development is proposed as a feasible treatment. CD40L-CD40-TRAF6 signal transduction plays a crucial role in inf...

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Bibliographic Details
Main Authors: Yaxian Huang, Jinyan Wu, Chi Zhan, Rong Liu, Zhaocai Zhou, Xin Huang, Yaguang Tian, Zhengmei Lin, Zhi Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
periodontitis
osteoclast
CD40L-CD40-TRAF6 axis
TRAF-STOP
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1119847/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1119847/full

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