Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction

Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction

Summary: Piezo2 is a mechanically activated ion channel required for touch discrimination, vibration detection, and proprioception. Here, we discovered that Piezo2 is extensively spliced, producing different Piezo2 isoforms with distinct properties. Sensory neurons from both mice and humans express...

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Bibliographic Details
Main Authors: Marcin Szczot, Leah A. Pogorzala, Hans Jürgen Solinski, Lynn Young, Philina Yee, Claire E. Le Pichon, Alexander T. Chesler, Mark A. Hoon
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717316728

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http://www.sciencedirect.com/science/article/pii/S2211124717316728

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