Mass‐produced gram‐negative bacterial outer membrane vesicles activate cancer antigen‐specific stem‐like CD8+ T cells which enables an effective combination immunotherapy with anti‐PD‐1

Mass‐produced gram‐negative bacterial outer membrane vesicles activate cancer antigen‐specific stem‐like CD8+ T cells which enables an effective combination immunotherapy with anti‐PD‐1

Abstract Despite the capability of extracellular vesicles (EVs) derived from Gram‐negative and Gram‐positive bacteria to induce potent anti‐tumour responses, large‐scale production of bacterial EVs remains as a hurdle for their development as novel cancer immunotherapeutic agents. Here, we developed...

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Bibliographic Details
Main Authors: Solchan Won, Changjin Lee, Seoyoon Bae, Jaemin Lee, Dongsic Choi, Min‐Gang Kim, Sunghyun Song, Jaewook Lee, Eunhye Kim, HaYoung Shin, Anita Basukala, Tae Ryong Lee, Dong‐Sup Lee, Yong Song Gho
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Journal of Extracellular Vesicles
Subjects:
bacterial extracellular vesicles
combination immunotherapy
immunotherapeutic agents
large‐scale mass production
outer membrane vesicles
Online Access:https://doi.org/10.1002/jev2.12357

Internet

https://doi.org/10.1002/jev2.12357

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