WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells

WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells

Abstract Background Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular endothelial cells (VEC) remained unclear. Recently, we showed that Wnt5A...

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Bibliographic Details
Main Authors: Tom Skaria, Esther Bachli, Gabriele Schoedon
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Inflammation
Subjects:
Inflammation
Endothelial permeability
Wnt5A
WIF1
Ryk
Cytoskeleton remodeling
Online Access:http://link.springer.com/article/10.1186/s12950-017-0157-4

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http://link.springer.com/article/10.1186/s12950-017-0157-4

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