HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma

HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma

Abstract Background Multiple myeloma (MM) is a malignancy of plasma cells that remains incurable. Toll-like receptor 4 (TLR4) acts as a stress-responsive signal, protecting mitochondria during proteasome inhibitor (PI) exposure, maintaining mitochondrial metabolism and increasing drug resistance in...

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Bibliographic Details
Main Authors: Lina Quan, Chuiming Jia, Yiwei Guo, Yao Chen, Xinya Wang, Qiuting Xu, Yu Zhang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Translational Medicine
Subjects:
HNRNPA2B1
TLR4
Multiple myeloma
N6-methyladenosine methylation
Online Access:https://doi.org/10.1186/s12967-022-03750-8

Internet

https://doi.org/10.1186/s12967-022-03750-8

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