Measurement of the pharmacokinetics and pharmacodynamics of neuroactive compounds

Measurement of the pharmacokinetics and pharmacodynamics of neuroactive compounds

The need to discover and develop safe and effective new medicines is greatest for disorders of the CNS. A core requirement for an effective neurotherapeutic agent is an ability to cross the blood–brain barrier and remain in the brain interstitial fluid (ISF) for a sufficient duration and concentrati...

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Bibliographic Details
Main Authors: Mohammad S. Alavijeh, Alan M. Palmer
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Neurobiology of Disease
Subjects:
Microdialysis
Receptor occupancy
Pharmacokinetics
Pharmacodynamics
Drug safety
Drug efficacy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002770

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http://www.sciencedirect.com/science/article/pii/S0969996109002770

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