Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions

Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions

Guanylate binding proteins (GBPs) are an evolutionarily ancient family of proteins that are widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases, and their expression can be partially induced by interferons (IFNs). GBPs are involved in the cell-autonomous innate imm...

Full description

Bibliographic Details
Main Authors: Luca Schelle, João Vasco Côrte-Real, Sharmeen Fayyaz, Augusto del Pozo Ben, Margarita Shnipova, Moritz Petersen, Rishikesh Lotke, Bhavna Menon, Dana Matzek, Lena Pfaff, Ana Pinheiro, João Pedro Marques, José Melo-Ferreira, Bastian Popper, Pedro José Esteves, Daniel Sauter, Joana Abrantes, Hanna-Mari Baldauf
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
GBP
evolution
innate immunity
antiviral proteins
cross-species conservation
lagomorphs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/full

Similar Items