Tumstatin, a Matrikine Derived from Collagen Type IVα3, is Elevated in Serum from Patients with Non–Small Cell Lung Cancer

OBJECTIVES: Fibrosis and cancer are characterized by extracellular matrix (ECM) remodeling. The basement membrane is mainly composed by collagen type IV and laminin. Tumstatin is a matrix metalloproteinase-9 (MMP-9) generated matrikine of collagen type IV α3 chain. We evaluated the potential of tums...

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Bibliographic Details
Main Authors: Signe Holm Nielsen, Nicholas Willumsen, Susanne Brix, Shu Sun, Tina Manon-Jensen, Morten Karsdal, Federica Genovese
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S193652331830010X