Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections. However, the dynamic responses of IBCs to host stresses and antibiotic therapy are difficult to assess in si...

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Bibliographic Details
Main Authors: Kunal Sharma, Neeraj Dhar, Vivek V Thacker, Thomas M Simonet, Francois Signorino-Gelo, Graham W Knott, John D McKinney
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
urinary tract infections
organ-on-chip
antibiotics
neutrophil extracellular traps
intracellular bacterial communities
time-lapse microscopy
Online Access:https://elifesciences.org/articles/66481

Internet

https://elifesciences.org/articles/66481

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