Inhibition of Complex I of the Respiratory Chain, but Not Complex III, Attenuates Degranulation and Cytokine Secretion in Human Skin Mast Cells

Inhibition of Complex I of the Respiratory Chain, but Not Complex III, Attenuates Degranulation and Cytokine Secretion in Human Skin Mast Cells

The mechanisms of mast cell (MC) degranulation and MC-driven skin symptoms are well-described. In contrast, data about the role of mitochondrial respiration for immune functions of human skin MCs are lacking. Oxygen consumption rate (OCR) in primary human skin MCs during IgE-mediated activation in t...

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Bibliographic Details
Main Authors: Thomas Buttgereit, Moritz Pfeiffenberger, Stefan Frischbutter, Pierre-Louis Krauß, Yuling Chen, Marcus Maurer, Frank Buttgereit, Timo Gaber
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
human skin mast cell
mitochondria
degranulation
myxothiazol
rotenone A
Online Access:https://www.mdpi.com/1422-0067/23/19/11591

Internet

https://www.mdpi.com/1422-0067/23/19/11591

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