Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway

Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway

Abstract Background The regulation of vascular smooth muscle cell (VSMC) phenotype plays an important role in intracranial aneurysm (IA) formation and progression. However, the underlying mechanism remains unclear. Metformin is a 5′ AMP-activated protein kinase (AMPK) agonist that has a protective e...

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Bibliographic Details
Main Authors: Sichen Li, Yuan Shi, Peixi Liu, Yaying Song, Yingjun Liu, Lingwen Ying, Kai Quan, Guo Yu, Zhiyuan Fan, Wei Zhu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Intracranial aneurysm
Metformin
AMPK
Vascular smooth muscle cell
Phenotype modulation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01868-4

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http://link.springer.com/article/10.1186/s12974-020-01868-4

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