A Novel Aldisine Derivative Exhibits Potential Antitumor Effects by Targeting JAK/STAT3 Signaling

A Novel Aldisine Derivative Exhibits Potential Antitumor Effects by Targeting JAK/STAT3 Signaling

The JAK/STAT3 signaling pathway is aberrantly hyperactivated in many cancers, promoting cell proliferation, survival, invasiveness, and metastasis. Thus, inhibitors targeting JAK/STAT3 have enormous potential for cancer treatment. Herein, we modified <b>aldisine</b> derivatives by introd...

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Bibliographic Details
Main Authors: Dong-Ping Wang, Li-Hong Wu, Rui Li, Na He, Qian-Yue Zhang, Chen-Yang Zhao, Tao Jiang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Marine Drugs
Subjects:
JAK/STAT3 signaling pathway
aldisine derivatives
isothiouronium
antitumor activity
JAK inhibitor
high-throughput screening
Online Access:https://www.mdpi.com/1660-3397/21/4/218

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https://www.mdpi.com/1660-3397/21/4/218

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