NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway

NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway

Abstract Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible for SRF regulation remain unclear. Here, we show that Nemo-like kinase (NLK) is req...

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Bibliographic Details
Main Authors: Shang-Ze Li, Ze-Yan Zhang, Jie Chen, Ming-You Dong, Xue-Hua Du, Jie Gao, Qi-Peng Shu, Chao Li, Xin-Yi Liang, Zhi-Hao Ding, Run-Lei Du, Junli Wang, Xiao-Dong Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00774-9

Internet

https://doi.org/10.1038/s41420-021-00774-9

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