Roxadustat Attenuates the Disruption of Epithelial Tight Junction in Caco2 Cells and a Rat Model of CKD Through MicroRNA-223

Roxadustat Attenuates the Disruption of Epithelial Tight Junction in Caco2 Cells and a Rat Model of CKD Through MicroRNA-223

IntroductionIncreasing evidence supports the idea that the disruption of epithelial tight junction proteins (TJPs) caused by accumulation of uremia toxins, such as homocysteine (Hcy), is one of the most important mechanisms underlying the damage of intestinal barrier function (IBF) in chronic kidney...

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Bibliographic Details
Main Authors: Ning Qu, Lei Chen, Shanshan Liang, Meng Wei, Lingshuang Sun, Quan He, Jinhong Xue, Meng Wang, Kehui Shi, Hongli Jiang, Hua Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Medicine
Subjects:
chronic kidney disease (CKD)
roxadustat
microRNA-223
tight junction proteins (TJPs)
hypoxia inducible factor-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.850966/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.850966/full

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