Dual phenotypes in recurrent astrocytoma, IDH-mutant; coexistence of IDH-mutant and IDH-wildtype components: a case report with genetic and epigenetic analysis

Dual phenotypes in recurrent astrocytoma, IDH-mutant; coexistence of IDH-mutant and IDH-wildtype components: a case report with genetic and epigenetic analysis

Abstract Mutations in the isocitrate dehydrogenase (IDH) gene are recognized as the key drivers in the oncogenesis of astrocytoma and oligodendroglioma. However, the significance of IDH mutation in tumor maintenance and malignant transformation has not been elucidated. We encountered a unique case o...

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Bibliographic Details
Main Authors: Junya Yamaguchi, Fumiharu Ohka, Masafumi Seki, Kazuya Motomura, Shoichi Deguchi, Yoshiki Shiba, Yuka Okumura, Yuji Kibe, Hiroki Shimizu, Sachi Maeda, Yuhei Takido, Ryo Yamamoto, Akihiro Nakamura, Kennosuke Karube, Ryuta Saito
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Acta Neuropathologica Communications
Subjects:
Astrocytoma
Loss of IDH mutation
Methylation analysis
PDGFRA amplification
CDKN2A/B homozygous deletion
Online Access:https://doi.org/10.1186/s40478-024-01879-9

Internet

https://doi.org/10.1186/s40478-024-01879-9

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