Initiation of TCR phosphorylation and signal transduction

Initiation of TCR phosphorylation and signal transduction

Recent data with CD8+ T cells show that the initial phase of TCR binding to MHCp is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the init...

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Bibliographic Details
Main Authors: Nicholas R.J. Gascoigne, Javier eCasas, Joanna eBrzostek, Vasily eRybakin
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Immunology
Subjects:
Signal Transduction
src-Family Kinases
tcr
Fyn
T cell receptor
Lck
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00072/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00072/full

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