Initiation of TCR phosphorylation and signal transduction
Recent data with CD8+ T cells show that the initial phase of TCR binding to MHCp is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the init...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00072/full |
| _version_ | 1811284154008993792 |
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| author | Nicholas R.J. Gascoigne Javier eCasas Joanna eBrzostek Vasily eRybakin |
| author_facet | Nicholas R.J. Gascoigne Javier eCasas Joanna eBrzostek Vasily eRybakin |
| author_sort | Nicholas R.J. Gascoigne |
| collection | DOAJ |
| description | Recent data with CD8+ T cells show that the initial phase of TCR binding to MHCp is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the bound TCR before the co-receptor binds to MHCp? |
| first_indexed | 2024-04-13T02:25:18Z |
| format | Article |
| id | doaj.art-f9f935d2865b4b1f9b1593763cec376a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T02:25:18Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f9f935d2865b4b1f9b1593763cec376a2022-12-22T03:06:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242011-12-01210.3389/fimmu.2011.0007215670Initiation of TCR phosphorylation and signal transductionNicholas R.J. Gascoigne0Javier eCasas1Joanna eBrzostek2Vasily eRybakin3The Scripps Research InstituteThe Scripps Research InstituteThe Scripps Research InstituteThe Scripps Research InstituteRecent data with CD8+ T cells show that the initial phase of TCR binding to MHCp is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the bound TCR before the co-receptor binds to MHCp?http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00072/fullSignal Transductionsrc-Family KinasestcrFynT cell receptorLck |
| spellingShingle | Nicholas R.J. Gascoigne Javier eCasas Joanna eBrzostek Vasily eRybakin Initiation of TCR phosphorylation and signal transduction Frontiers in Immunology Signal Transduction src-Family Kinases tcr Fyn T cell receptor Lck |
| title | Initiation of TCR phosphorylation and signal transduction |
| title_full | Initiation of TCR phosphorylation and signal transduction |
| title_fullStr | Initiation of TCR phosphorylation and signal transduction |
| title_full_unstemmed | Initiation of TCR phosphorylation and signal transduction |
| title_short | Initiation of TCR phosphorylation and signal transduction |
| title_sort | initiation of tcr phosphorylation and signal transduction |
| topic | Signal Transduction src-Family Kinases tcr Fyn T cell receptor Lck |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00072/full |
| work_keys_str_mv | AT nicholasrjgascoigne initiationoftcrphosphorylationandsignaltransduction AT javierecasas initiationoftcrphosphorylationandsignaltransduction AT joannaebrzostek initiationoftcrphosphorylationandsignaltransduction AT vasilyerybakin initiationoftcrphosphorylationandsignaltransduction |