Initiation of TCR phosphorylation and signal transduction
Recent data with CD8+ T cells show that the initial phase of TCR binding to MHCp is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the init...
Main Authors: | Nicholas R.J. Gascoigne, Javier eCasas, Joanna eBrzostek, Vasily eRybakin |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2011-12-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00072/full |
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