Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway

Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway

Abstract Background Encouraged by the goal of developing an effective treatment strategy for prostate cancer, this study explored the mechanism involved in metformin-mediated inhibition of AR-negative prostate cancer. Methods Cell behaviors of DU145 and PC3 cells were determined by CCK8 test, colony...

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Bibliographic Details
Main Authors: Chunyang Chen, He Wang, Xinyu Geng, Dongze Zhang, Zhengyu Zhu, Guangbo Zhang, Jianquan Hou
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Cancer Cell International
Subjects:
Metformin
Autophagy
Prostate cancer
AMPK
LC3B
Online Access:https://doi.org/10.1186/s12935-021-02043-2

Internet

https://doi.org/10.1186/s12935-021-02043-2

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