Design rules for selective binding of nuclear localization signals to minor site of importin α.

Design rules for selective binding of nuclear localization signals to minor site of importin α.

Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...

Bibliografiset tiedot
Päätekijät:	Xiaodong Pang, Huan-Xiang Zhou
Aineistotyyppi:	Artikkeli
Kieli:	English
Julkaistu:	Public Library of Science (PLoS) 2014-01-01
Sarja:	PLoS ONE
Linkit:	http://europepmc.org/articles/PMC3946659?pdf=render

Samankaltaisia teoksia

Acetylation of the nuclear localization signal in Ku70 diminishes the interaction with importin-α
Tekijä: Hirofumi Fujimoto, et al.
Julkaistu: (2023-03-01)

Human Enzyme PADI4 Binds to the Nuclear Carrier Importin α3
Tekijä: José L. Neira, et al.
Julkaistu: (2022-07-01)

Differential Behaviours and Preferential Bindings of Influenza Nucleoproteins on Importins-α
Tekijä: Amélie Donchet, et al.
Julkaistu: (2020-07-01)

Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal
Tekijä: Yoshiyuki Matsuura
Julkaistu: (2023-04-01)

Structural Basis for Importin-α Binding of the Human Immunodeficiency Virus Tat
Tekijä: K. M. Smith, et al.
Julkaistu: (2017-05-01)

The adapter importin‐α provides flexible control of nuclear import at the expense of efficiency
Tekijä: Greg Riddick, et al.
Julkaistu: (2007-06-01)

A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin
Tekijä: José L. Neira, et al.
Julkaistu: (2020-09-01)

Nuclear Trafficking of the Rabies Virus Interferon Antagonist P-Protein Is Regulated by an Importin-Binding Nuclear Localization Sequence in the C-Terminal Domain.
Tekijä: Caitlin L Rowe, et al.
Julkaistu: (2016-01-01)

Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells
Tekijä: Akiko Yamada, et al.
Julkaistu: (2024-01-01)

Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.
Tekijä: A Reum Jang, et al.
Julkaistu: (2015-02-01)

Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
Tekijä: Marzia Indrigo, et al.
Julkaistu: (2023-10-01)

Co-translational binding of importins to nascent proteins
Tekijä: Maximilian Seidel, et al.
Julkaistu: (2023-06-01)

Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors
Tekijä: Kelley Joshua B, et al.
Julkaistu: (2010-08-01)

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer
Tekijä: Sundy N. Y. Yang, et al.
Julkaistu: (2019-03-01)

UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner.
Tekijä: Zhengke Li, et al.
Julkaistu: (2013-01-01)

Correction: Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.
Tekijä: PLOS Genetics Staff
Julkaistu: (2015-04-01)

Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts
Tekijä: Zhiqiang Duan, et al.
Julkaistu: (2018-12-01)

Beta-Like Importins Mediate the Nuclear Translocation of MAPKs
Tekijä: Eldar Zehorai, et al.
Julkaistu: (2019-04-01)

Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha.
Tekijä: Jessica J Chaston, et al.
Julkaistu: (2017-01-01)

Data on dimer formation between importin α subtypes
Tekijä: Yoichi Miyamoto, et al.
Julkaistu: (2016-06-01)

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS
Tekijä: Valovka Taras, et al.
Julkaistu: (2008-07-01)

Nuclear Import of Arabidopsis Poly(ADP-Ribose) Polymerase 2 Is Mediated by Importin-α and a Nuclear Localization Sequence Located Between the Predicted SAP Domains
Tekijä: Chao Chen, et al.
Julkaistu: (2018-11-01)

Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal
Tekijä: Mikayla Hoad, et al.
Julkaistu: (2023-01-01)

Distinct mutations in importin-β family nucleocytoplasmic transport receptors transportin-SR and importin-13 affect specific cargo binding
Tekijä: Makoto Kimura, et al.
Julkaistu: (2021-08-01)

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.
Tekijä: Katinka Döhner, et al.
Julkaistu: (2018-01-01)

Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin
Tekijä: Sara Artigas-Jerónimo, et al.
Julkaistu: (2021-04-01)

Yeast importin-β is required for nuclear import of the Mig2 repressor
Tekijä: Fernández-Cid Alejandra, et al.
Julkaistu: (2012-11-01)

Drosophila Importin-α2 is involved in synapse, axon and muscle development.
Tekijä: Timothy J Mosca, et al.
Julkaistu: (2010-12-01)

Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
Tekijä: Chih-Chia Chang, et al.
Julkaistu: (2019-09-01)

Neurospora importin α is required for normal heterochromatic formation and DNA methylation.
Tekijä: Andrew D Klocko, et al.
Julkaistu: (2015-03-01)

The LSD1-type zinc finger motifs of Pisum sativa LSD1 are a novel nuclear localization signal and interact with importin alpha.
Tekijä: Shanping He, et al.
Julkaistu: (2011-01-01)

Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation
Tekijä: Domenica Ippolito, et al.
Julkaistu: (2021-11-01)

The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation.
Tekijä: Nalani Sachan, et al.
Julkaistu: (2013-01-01)

Maternal Nanos inhibits Importin-α2/Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.
Tekijä: Miho Asaoka, et al.
Julkaistu: (2019-05-01)

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import
Tekijä: Thomas Vercruysse, et al.
Julkaistu: (2024-11-01)

Viral Targeting of Importin Alpha-Mediated Nuclear Import to Block Innate Immunity
Tekijä: Olivia A. Vogel, et al.
Julkaistu: (2023-12-01)

Importins involved in the nuclear transportation of steroid hormone receptors: In silico and in vitro data
Tekijä: Konstantina Kalyvianaki, et al.
Julkaistu: (2022-09-01)

The Nuclear Transport Protein Importin-5: A Promising Target in Oncology and Virology
Tekijä: Rémi Patouret
Julkaistu: (2021-04-01)

Importin α7 is essential for zygotic genome activation and early mouse development.
Tekijä: Franziska Rother, et al.
Julkaistu: (2011-03-01)

Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast
Tekijä: Ignacio Flor-Parra, et al.
Julkaistu: (2018-04-01)