Peritumoral administration of DRibbles-pulsed antigen-presenting cells enhances the antitumor efficacy of anti-GITR and anti-PD-1 antibodies via an antigen presenting independent mechanism

Peritumoral administration of DRibbles-pulsed antigen-presenting cells enhances the antitumor efficacy of anti-GITR and anti-PD-1 antibodies via an antigen presenting independent mechanism

Abstract Background TNF receptor family agonists and checkpoint blockade combination therapies lead to minimal tumor clearance of poorly immunogenic tumors. Therefore, a need to enhance the efficacy of this combination therapy arises. Antigen-presenting cells (APCs) present antigen to T cells and st...

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Bibliographic Details
Main Authors: Jaina M. Patel, Zhihua Cui, Zhi-Fa Wen, Catherine T. Dinh, Hong-Ming Hu
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
GITR
PD-1
Antigen presenting cells
Dendritic cells
Peritumoral injection
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s40425-019-0786-7

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http://link.springer.com/article/10.1186/s40425-019-0786-7

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