Transmembrane Batten Disease Proteins Interact With a Shared Network of Vesicle Sorting Proteins, Impacting Their Synaptic Enrichment

Transmembrane Batten Disease Proteins Interact With a Shared Network of Vesicle Sorting Proteins, Impacting Their Synaptic Enrichment

Batten disease is unique among lysosomal storage disorders for the early and profound manifestation in the central nervous system, but little is known regarding potential neuron-specific roles for the disease-associated proteins. We demonstrate substantial overlap in the protein interactomes of thre...

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Bibliographic Details
Main Authors: Mitchell J. Rechtzigel, Brandon L. Meyerink, Hannah Leppert, Tyler B. Johnson, Jacob T. Cain, Gavin Ferrandino, Danielle G. May, Kyle J. Roux, Jon J. Brudvig, Jill M. Weimer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Neuroscience
Subjects:
lysosome
neurodegeneration
vesicle traffic
Batten disease
SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor)
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.834780/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.834780/full

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