Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia

Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a common disease in aging males. It has been proven that the Hedgehog (HH) is implied as an effective and fundamental regulatory growth factor signal for organogenesis, homeostasis, and regeneration. Smoothened (SMO), as the major control point of HH si...

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Bibliographic Details
Main Authors: Jianmin Liu, Jing Yin, Ping Chen, Daoquan Liu, Weixiang He, Yan Li, Mingzhou Li, Xun Fu, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00501-4

Internet

https://doi.org/10.1038/s41420-021-00501-4

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