Protection from cisplatin-induced hearing loss with lentiviral vector-mediated ectopic expression of the anti-apoptotic protein BCL-XL

Protection from cisplatin-induced hearing loss with lentiviral vector-mediated ectopic expression of the anti-apoptotic protein BCL-XL

Cisplatin is a highly effective chemotherapeutic agent, but it can cause sensorineural hearing loss (SNHL) in patients. Cisplatin-induced ototoxicity is closely related to the accumulation of reactive oxygen species (ROS) and subsequent death of hair cells (HCs) and spiral ganglion neurons (SGNs). D...

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Bibliographic Details
Main Authors: Larissa Nassauer, Hinrich Staecker, Peixin Huang, Bryan Renslo, Madeleine Goblet, Jennifer Harre, Athanasia Warnecke, Juliane W. Schott, Michael Morgan, Melanie Galla, Axel Schambach
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
hearing loss
ototoxicity
cisplatin
gene therapy
lentiviral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124000441

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http://www.sciencedirect.com/science/article/pii/S2162253124000441

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