AGEs-RAGE-KCa3.1 pathway mediates palmitic acid-induced migration of PBMCs from patients with type 2 diabetes

AGEs-RAGE-KCa3.1 pathway mediates palmitic acid-induced migration of PBMCs from patients with type 2 diabetes

Type 2 diabetes mellitus (T2DM) is characterized by chronic low-grade systemic inflammation. Tissue infiltration by monocyte migration contributes to the pathogenesis of vascular complications in T2DM. We studied the role of intermediate-conductance Ca2+-activated K+ (KCa3.1) channels in the palmiti...

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Bibliographic Details
Main Authors: Yi Zhang, Xiao-Zhen Ma, Xin-Yi Zhao, Jing-Jing Li, Shan Ma, Zheng-Da Pang, Jing Xu, Xiao-Jun Du, Xiu-Ling Deng, Jun-Hong Wang
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Heliyon
Subjects:
Peripheral blood mononuclear cells
Migration
Palmitic acid
HbA1c
Type 2 diabetes mellitus
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023020303

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http://www.sciencedirect.com/science/article/pii/S2405844023020303

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