20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice.

20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice.

Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ozone-induced AHR in murine airways.Male BALB/c mice were exposed to ozone (3 or 6 ppm) or fil...

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Bibliographic Details
Main Authors: Philip R Cooper, A Clementina Mesaros, Jie Zhang, Peter Christmas, Christopher M Stark, Karim Douaidy, Michael A Mittelman, Roy J Soberman, Ian A Blair, Reynold A Panettieri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2857875?pdf=render

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http://europepmc.org/articles/PMC2857875?pdf=render

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