Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs

Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs

FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has become one of the hotspots in current pharmaceutical...

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Bibliographic Details
Main Authors: Qiaohua Qin, Ruifeng Wang, Qinglin Fu, Guoqi Zhang, Tianxiao Wu, Nian Liu, Ruicheng Lv, Wenbo Yin, Yin Sun, Yixiang Sun, Dongmei Zhao, Maosheng Cheng
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
FAK
PROTACs
PF-562271
A549 cells
protein degradation
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2100886

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2022.2100886

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