Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation.

Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation.

A novel neutrophil chemoattractant derived from collagen, proline-glycine-proline (PGP), has been recently characterized in chronic obstructive pulmonary disease (COPD). This peptide is derived via the proteolytic activity of matrix metalloproteases (MMP's)-8/9 and PE, enzymes produced by neutr...

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Bibliographic Details
Main Authors: Mojtaba Abdul Roda, Mariam Sadik, Amit Gaggar, Matthew T Hardison, Michael J Jablonsky, Saskia Braber, James Edwin Blalock, Frank A Redegeld, Gert Folkerts, Patricia L Jackson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4023971?pdf=render

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http://europepmc.org/articles/PMC4023971?pdf=render

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