A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis

A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis

Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid commonly used for treating cholestatic liver disease. However, its efficacy on non-alcoholic steatohepatitis (NASH) was controversial. This study aimed to investigate the impact of a high dosage of UDCA on a mouse model of NASH. Forty 6-week-old...

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Bibliographic Details
Main Authors: Hu Li, Mingjie Wang, Peizhan Chen, Mingyu Zhu, Li Chen
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Non-alcoholic fatty liver disease
Ursodeoxycholic acid
Gut microbiota
Bile acids
Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224005018

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http://www.sciencedirect.com/science/article/pii/S0753332224005018

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