Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Summary: Background: Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. Methods: We obtained the lung specimens from the patients who died of COVID-19. The...

Full description

Bibliographic Details
Main Authors: Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu Ma, Jowaly Schneider, John T. Skinner, Beejan Asady, Erin Goerlich, Marc K. Halushka, Allison G. Hays, Deok-Ho Kim, Chirag R. Parikh, Avi Z. Rosenberg, Isabelle Coppens, Roger A. Johns, Nisha A. Gilotra, Jody E. Hooper, Andrew Pekosz, Daniela Čiháková
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:EBioMedicine
Subjects:
COVID-19
SARS-CoV-2
immunothrombosis
endothelial cell dysfunction
thrombomodulin
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422000019

Internet

http://www.sciencedirect.com/science/article/pii/S2352396422000019

Similar Items