Fundamental Sex Differences in Cocaine-Induced Plasticity of Dopamine D1 Receptor– and D2 Receptor–Expressing Medium Spiny Neurons in the Mouse Nucleus Accumbens Shell

Fundamental Sex Differences in Cocaine-Induced Plasticity of Dopamine D1 Receptor– and D2 Receptor–Expressing Medium Spiny Neurons in the Mouse Nucleus Accumbens Shell

Background: Cocaine-induced plasticity in the nucleus accumbens shell of males occurs primarily in dopamine D1 receptor–expressing medium spiny neurons (D1R-MSNs), with little if any impact on dopamine D2 receptor–expressing medium spiny neurons (D2R-MSNs). In females, the effect of cocaine on accum...

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Bibliographic Details
Main Authors: Andrew D. Chapp, Chinonso A. Nwakama, Pramit P. Jagtap, Chau-Mi H. Phan, Mark J. Thomas, Paul G. Mermelstein
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biological Psychiatry Global Open Science
Subjects:
Cocaine
Estrous cycle
Excitability
mEPSCs
Nucleus accumbens shell
Sex differences
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174324000089

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http://www.sciencedirect.com/science/article/pii/S2667174324000089

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