Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

Summary: Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders, including Alzheimer disease (AD). Here, we asked whether early PV neuron hyperexcitability primes the hippocampus for amyloid beta-induced functional impairment. We show that prolonged chemogenetic activati...

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Bibliographic Details
Main Authors: Sara Hijazi, Tim S. Heistek, Rolinka van der Loo, Huibert D. Mansvelder, August B. Smit, Ronald E. van Kesteren
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:iScience
Subjects:
Neuroscience
Systems Neuroscience
Cellular Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220304570

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http://www.sciencedirect.com/science/article/pii/S2589004220304570

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