Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration

Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration

Abstract Background Intervertebral disc (IVD) is a highly rhythmic tissue, which experiences a diurnal cycle of high/low mechanical loading via the changes of activity/rest phase. There are signs that disruption of the peripheral IVD clock is related to the process of intervertebral disc degeneratio...

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Bibliographic Details
Main Authors: Pandi Peng, Dong Wang, Xiaolong Xu, Di Wang, Bo Gao, Han Wang, Haoruo Jia, Qiliang Shang, Chao Zheng, Chu Gao, Jianxin Mao, Zhuojing Luo, Liu Yang, Xueyu Hu
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Arthritis Research & Therapy
Subjects:
Intervertebral disc degeneration
Circadian rhythms
Bmal1
NRF2
Inflammation
Online Access:https://doi.org/10.1186/s13075-022-02876-w

Internet

https://doi.org/10.1186/s13075-022-02876-w

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