Leptin deficiency in CD8+ T cells ameliorates non-segmental vitiligo by reducing interferon-γ and Granzyme B

Leptin deficiency in CD8+ T cells ameliorates non-segmental vitiligo by reducing interferon-γ and Granzyme B

BackgroundVitiligo is an autoimmune skin disease mainly mediated by CD8+ T cells, which affects about 0.1%-2% population of the world. Leptin plays a critical role in regulating the activation of CD8+ T cells. However, the effect of Leptin on vitiligo remains unclear.ObjectivesTo explore the effect...

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Bibliographic Details
Main Authors: Meiyu Wu, Lu Wang, Haijing Wu, Ming Yang, Zhenghao He, Yiran Chen, Huiming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
Leptin
vitiligo
CD8+ T cells
autoimmune disease
lipid metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158883/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158883/full

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