SIRT1-dependent deacetylation of Txnip H3K9ac is critical for exenatide-improved diabetic kidney disease

SIRT1-dependent deacetylation of Txnip H3K9ac is critical for exenatide-improved diabetic kidney disease

Glucagon-like peptide 1 receptor agonist exenatide (exendin-4) has potential protective capabilities against diabetic kidney disease (DKD). However, the underlying mechanism has not been fully elucidated. The expression of thioredoxin-interacting protein (Txnip) is upregulated during DKD progression...

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Bibliographic Details
Main Authors: Mei-jun Wang, Xiang Cai, Ri-ying Liang, En-ming Zhang, Xiao-qi Liang, Hua Liang, Chang Fu, An-dong Zhou, Yi Shi, Fen Xu, Meng-yin Cai
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Exenatide
Txnip
Kidney-specific Sirt1 knockout
Diabetic kidney disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223013136

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http://www.sciencedirect.com/science/article/pii/S0753332223013136

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