Combining immunotherapy with high-dose radiation therapy (HDRT) significantly inhibits tumor growth in a syngeneic mouse model of high-risk neuroblastoma

Combining immunotherapy with high-dose radiation therapy (HDRT) significantly inhibits tumor growth in a syngeneic mouse model of high-risk neuroblastoma

Purpose: The mortality in patients with MYCN-amplified high-risk neuroblastoma remains greater than 50% despite advances in multimodal therapy. Novel therapies are urgently needed that requires preclinical evaluation in appropriate mice models. Combinatorial treatment with high-dose radiotherapy (HD...

Full description

Bibliographic Details
Main Authors: Shuobo Boboila, Shunpei Okochi, Debarshi Banerjee, Sunjay Barton, Cherease Street, Ariela L. Zenilman, Qi Wang, Robyn D. Gartrell, Yvonne M. Saenger, David Welch, Cheng-Chia Wu, Angela Kadenhe-Chiweshe, Darrell J. Yamashiro, Eileen P. Connolly
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Novel syngeneic mouse model
Neuroblastoma
High dose radiation therapy
Immunotherapy
MYCN-amplified neuroblastoma
Cancer therapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023046078

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023046078

Similar Items