ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer

ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer

The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containi...

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Bibliographic Details
Main Authors: Prachi Mishra, Wei Tang, Stefan Ambs
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:Molecular & Cellular Oncology
Subjects:
breast cancer
metabolism
oncogene
2-hydroxyglutarate
myc signaling
mechanisms of oncogenesis and tumor progression
oncogenes and tumor suppressor genes
tumor metabolism
Online Access:http://dx.doi.org/10.1080/23723556.2018.1432260

Internet

http://dx.doi.org/10.1080/23723556.2018.1432260

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