ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1432260 |
| _version_ | 1797677184725286912 |
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| author | Prachi Mishra Wei Tang Stefan Ambs |
| author_facet | Prachi Mishra Wei Tang Stefan Ambs |
| author_sort | Prachi Mishra |
| collection | DOAJ |
| description | The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis. |
| first_indexed | 2024-03-11T22:41:23Z |
| format | Article |
| id | doaj.art-fa286d9d84654b2eaca9071803eb1c20 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:23Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-fa286d9d84654b2eaca9071803eb1c202023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-05-015310.1080/23723556.2018.14322601432260ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancerPrachi Mishra0Wei Tang1Stefan Ambs2Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH)Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH)Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH)The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis.http://dx.doi.org/10.1080/23723556.2018.1432260breast cancermetabolismoncogene2-hydroxyglutaratemyc signalingmechanisms of oncogenesis and tumor progressiononcogenes and tumor suppressor genestumor metabolism |
| spellingShingle | Prachi Mishra Wei Tang Stefan Ambs ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer Molecular & Cellular Oncology breast cancer metabolism oncogene 2-hydroxyglutarate myc signaling mechanisms of oncogenesis and tumor progression oncogenes and tumor suppressor genes tumor metabolism |
| title | ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer |
| title_full | ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer |
| title_fullStr | ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer |
| title_full_unstemmed | ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer |
| title_short | ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer |
| title_sort | adhfe1 is a myc linked oncogene that induces metabolic reprogramming and cellular de differentiation in breast cancer |
| topic | breast cancer metabolism oncogene 2-hydroxyglutarate myc signaling mechanisms of oncogenesis and tumor progression oncogenes and tumor suppressor genes tumor metabolism |
| url | http://dx.doi.org/10.1080/23723556.2018.1432260 |
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