Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition

Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition

Triphenyl phosphate (TPHP) is a widely used organophosphate flame retardant and has biological toxicity. Previous studies showed TPHP can restrain testosterone biosynthesis in Leydig cells, while the underlying mechanisms remain unclear. In this study, C57BL/6J male mice were exposed to 0, 5, 50, an...

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Bibliographic Details
Main Authors: Minxin Wang, Jinyu Xu, Zhengbo Zhao, Lichao Gong, Yu Su, Zhichao Fang, Pengfei Chen, Yifan Liu, Lianshuang Zhang, Feibo Xu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Triphenyl phosphate
Leydig cells
Apoptosis
Mitochondrial fusion and fission
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323003809

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http://www.sciencedirect.com/science/article/pii/S0147651323003809

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