C9orf72 polyPR directly binds to various nuclear transport components

C9orf72 polyPR directly binds to various nuclear transport components

The disruption of nucleocytoplasmic transport (NCT) is an important mechanism in neurodegenerative diseases. In the case of C9orf72-ALS, trafficking of macromolecules through the nuclear pore complex (NPC) might get frustrated by the binding of C9orf72-translated arginine-containing dipeptide repeat...

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Bibliographic Details
Main Authors: Hamidreza Jafarinia, Erik van der Giessen, Patrick R Onck
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
C9orf72
ALS/FTD
nuclear pore complex
nucleocytoplasmic transport
importins/exportins
molecular dynamics
Online Access:https://elifesciences.org/articles/89694

Internet

https://elifesciences.org/articles/89694

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