Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing.

Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing.

RNA viruses cause numerous infectious diseases in humans and animals. The crosstalk between RNA viruses and the innate DNA sensing pathways attracts increasing attention. Recent studies showed that the cGAS-STING pathway plays an important role in restricting RNA viruses via mitochondria DNA (mtDNA)...

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Bibliographic Details
Main Authors: Ya Yan, Lei Wu, Ye Yuan, Haiwei Wang, Hongyan Yin, Minjie Li, Lvye Chai, Ruiying Liang, Yanjie Liu, Dongming Zhao, Junji Xing, Pingwei Li, Xin Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011641

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https://doi.org/10.1371/journal.ppat.1011641

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