RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

Ferroptosis is an iron-dependent, oxidative cell death, and is characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. It has been implicated in various human diseases, including cancer. Recently, ferroptosis, as a non-apoptotic form of cell death, is emerging...

Full description

Bibliographic Details
Main Authors: Xinbing Sui, Ruonan Zhang, Shuiping Liu, Ting Duan, Lijuan Zhai, Mingming Zhang, Xuemeng Han, Yu Xiang, Xingxing Huang, Haoming Lin, Tian Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
RSL3
ferroptosis
glutathione peroxidase 4
reactive oxygen species
colorectal cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01371/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01371/full

Similar Items